When aRNA driven by a tumor-specific promoter was transiently transfected into cells, amiRNA targeting MYC can be expressed to markedly decrease the mRNA and protein expression levels of oncogenic MYC and significantly inhibit cell growth in vitro, induce apoptosis and suppress the migration of bladder cancer cells, but not human foreskin fibroblast cells. Here, MYC is linked to urinary bladder carcinoma.