PON1 and type 2 diabetes mellitus: HDL becomes “dysfunctional” inter alia in type 2 diabetes [5], which may mean that also in pathological state relative composition of lipids and proteins in HDL, as well as enzymatic activities associated to HDL, such as paraoxonase 1 (PON1) and lipoprotein-associated phospholipase 11 (Lp-PLA2), are altered [22].