This data is in agreement with previous results showing the H2 allele expresses two-fold higher exon 3-containing transcripts when compared to H1 [19, 48] We quantified the expression levels of exon 3-containing transcripts in comparison to total MAPT expression, as determined by qPCR, from our H1 and H2 wild-type vectors in SK-N-F1 neuroblastoma cells (Fig. 2b). Here, MAPT is linked to neuroblastoma.