BRAF and cancer: By sequencing BRAF genefrom normal gastric biopsies of the HCL patient, germline mutation is excluded [27].Our report is the first time to detect F468C germline mutation in a non-cancer patient.Patients 6&9presented similar clinical characteristics, which supported the idea that the phenotype resulting from BRAF mutations is allele-specific and suggested that residue 468 may be a “hotspot” mutation site in Chinese patients.