However, F468Cwas never been reported in NS or related disorderspreviously.Interestingly, itwas detected in paraffin-embedded tumoursepecimens of a hairy cell leukemia (HCL) patient [27] and a colorectal cancer patient [28].There is evidence from in vitro and in vivotransfection experiments [29] that F468C mutation leads to increased activity of BRAF and may thus be disease-defining mutation of HCL or colorectal cancer. This evidence concerns the gene BRAF and hairy cell leukemia.