BRAF and malignant colon neoplasm: Taken together, the row of yellow plots in Fig. 2 (plots m-o) indicate significant overall up-regulation of miR-196a-5p in 567 proximal colon cancer patients (left plot), similarly significant up-regulation of the same microRNA in 391 proximal colon cancer patients whose tumors lack the BRAF mutation (center plot), but significant down-regulation of the same microRNA in 73 proximal colon cancer patients whose tumors have the BRAF mutation.