Within 30–60 min post infection (p.i.), early SCV matures into late SCV by loss of early endosomal proteins and simultaneous acquisition of selective late endosomal and lysosomal proteins including Rab7, lysosomal glycoproteins (lgps) such as, LAMP1 and LAMP2 and v-ATPases [5,7]. The gene discussed is LAMP1; the disease is infection.