Given the heterogeneity of TAMs, we assessed the ability of TTI-621 to trigger phagocytosis of lymphoma cells by the different macrophage populations, and found that blockade of CD47 using TTI-621 dramatically increased phagocytosis of lymphoma cells by all subsets, relative to cultures treated with control Fc fragment, with M(IFN-γ), M(IFN-γ+LPS) and M(IL-10 + TGFβ) MDMs being superior at phagocytosis (Fig 1 and S2 Fig). Here, TGFB1 is linked to lymphoma.