Serum levels of pro-inflammatory molecules including interleukin-4 (IL-4), tumor necrosis factor alpha (TNF-α), soluble interleukin-2 receptor (sIL-2R), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), soluble receptor of TNF-α type 1 (STNFR1) and CRP are elevated in BD patients compared to healthy controls [3,47,48,49]. This evidence concerns the gene TNF and Behcet disease.