NOS3 and atrial fibrillation: Finally, in this matter, a study conducted in rabbits showed that resveratrol could revert an abnormal signaling, via gene expression activation of phosphoinositide 3-kinase (PI3K)/Protein kinase B (Akt)/endothelial nitric oxide synthase (eNOS) axis, which play a role in the inhibition of pathological signaling cascades in AF, and hence correcting the action potential duration, causing a suppression on AF [15].