GJA1 and atrial fibrillation: An investigation into the effects of a new pure DHA derivative called F 16915, in experimental rat and dog models of HF-induced atrial dysfunction, showed that F 16915 (5 g/day for 4 weeks) significantly reduced the incidence of sustained AF in the dog model and also reduced the non-functional dephosphorylated form of Cx43 in rat atrial tissue [89].