Alternatively, use of neonatal mice or knockout mice (e.g. of IFN-α/βR, STAT-1) have been required to mimic human disease for Ebola, Marburg, Lassa, Nipah, or Zika viruses in mice, and only through expression of human DPP4 (receptor for MERS CoV) in mouse lungs could infection of mice with MERs CoV be achieved.45 This evidence concerns the gene DPP4 and infection.