In the present study, we found that both IL‐1β, IL‐6 and IL‐8 transcript levels and IL‐1β/IL‐6 secretion were effectively suppressed in LPS‐induced MH7A cells and FLS by selective CDK7 inhibitor BS‐181 as well as CDK7 knockdown, which is coincident with that of CDK7 inhibition ameliorated experimental arthritis 22, suggesting that CDK7 inhibition strongly impeded RA inflammation. This evidence concerns the gene IL1B and arthritic joint disease.