CD274 and neoplasm: While our results of correlation between JAK2 genetic alteration and PD-L1 expression in TCGA genomic data only suggests the JAK2 p.V617F mutation may correlate with high level PD-L1 expression, a direct analysis of IHC-based PD-L1 expression in tumor samples of NSCLCs carrying the JAK2 p.V617F mutation is essential when such data become available in the future.