We then tested co-occurrence or mutual exclusivity of the JAK2 p.V617F mutation with other well-characterized lung cancer genes including RAS family genes (KRAS, NRAS, HRAS), EGFR, BRAF, and HER2. As expected, mutations in the RAS genes, EGFR, BRAF, and HER2, are largely mutually exclusive. This evidence concerns the gene HRAS and lung carcinoma.