The importance of MnSOD has resulted in investigation of its role in different diseases including breast cancer, prostate cancer, gastric cancer, rectal and colorectal cancer, lung cancer, kidney cancer, many neurodegenerative diseases including Alzheimer and Parkinson, aging process, infertility and spontaneous abortion and also in studying mental and behavioral disorders (12, 16, 22). This evidence concerns the gene SOD2 and kidney cancer.