ANGPTL8 and type 2 diabetes mellitus: This was in accordance with Guo et al.'s study in obese individuals [15] and Hu et al.'s in newly diagnosed type 2 diabetes [6].One reason for the discrepancy as Fu et al. described was the differences in ANGPTL8 antibodies, being against the N-terminus or the C-terminus, in ELISA kits used in different studies [16].