And high PLR tended toward a lower effect of DFS on HER2+ (HR = 1.29, 95% CI = 0.85–1.96, Tau2 = 0.155, and I2 = 69.2%) and negative hormone receptors (ER− and PR−) (HR = 1.14, 95% CI = 0.93–1.41, Tau2 < 0.001, and I2 = 0.0%) breast cancer, although statistical significance was not reached. Here, ESR1 is linked to breast cancer.