Plasma PLP significantly correlated with CRP levels, while plasma PL significantly correlated with IL-10 level and plasma PLP + PL significantly correlated with CRP and IL-1β levels after adjusting for age, gender, BMI, SBP, serum albumin concentration, diabetes, CKD stage, B-vitamin supplement use, smoking, and drinking habits and finally additionally adjusting for plasma homocysteine concentration (Table 3). This evidence concerns the gene IL1B and chronic kidney disease.