The morphological feature of signet-ring cell carcinoma and adenocarcinoma of apocrine had been identified in our sample cohort, and no significant difference of expression of ER (P = 0.496) or AR (P = 0.514) between the 19 signet-ring cell carcinomas and 141 adenocarcinomas of apocrine, respectively. The gene discussed is ESR1; the disease is signet ring cell carcinoma.