After combination of ER and AR, coexpression of ER and AR was found in 12 out of 72 (16.67%) EMPD cases and only in 3 out of 88 (3.41%) MPD cases, the ER-AR expression pattern was significantly different between MPD and EMPD (P < 0.001, Table 3). Here, ESR1 is linked to extramammary Paget disease.