HMGB1 and hydrops fetalis: Fig. 1 shows that circulating levels of NT-proBNP (a), hs-troponin T (b), and galectin-3 (c) increased with worsening NYHA class; whereas levels of HMGB1 (d) were elevated similarly in NYHA class II–IV HF and levels of calprotectin (e) were only elevated in NYHA class IV HFrEF.