BAX and posterior cortical atrophy: Furthermore, the expression of proapoptosis protein Bax was significantly upregulated in high concentration groups (80 μg/ml for PANC1 cells and 10 μg/ml for BxPC3 cells), and the expression of antiapoptosis protein Bcl2 was downregulated in the same groups (Figure 6), demonstrating that curcumin promoted apoptosis of PCa cells.