The serum IFN-α level was significantly higher in DF patients than in DHF patients, irrespective of the DENV serotypes [20], and the dynamic change of serum level significantly reduced in 3–5 days after fever onset (DENV-1: reduced from 94.42 pg/mL to 36.12 pg/mL; DENV-2: reduced from 53.39 pg/mL to 38.25 pg/mL). The gene discussed is IFNA1; the disease is dengue disease.