There is emerging theoretical evidence for the use of IL1β-regulating antibody agents such as Gevokizumab [135, 136], Anakinra [137–140], and Canakinumab [141–144] in BD, and another orphan drug from this group Rilonacept has been successfully used in other autoinflammatory syndromes [145, 146]. Here, IL1B is linked to Behcet disease.