Other biological agents that are currently or have previously been considered worthy of consideration in the treatment of BD include the IL-12/23 monoclonal antibody-Ustekinumab [160, 161], B-cell depletion antibodies-Rituximab [162–166], Belimumab, and the competitive binding to CD80 and CD86 costimulator antibody-Abatacept which is currently undergoing an open-label clinical trial in the treatment of mucocutaneous manifestations of BD [167]. The gene discussed is CD86; the disease is Behcet disease.