In addition to strong zones of cis-regulation of IGF2BP2 itself, three of the transancestral eQTL SNPs within intron 1 of IGF2BP2 regulate diabetes and obesity related genes in trans (i.e., RBM47 Benton et al., 2015, KIAA1430 Sandholm et al., 2017, and DIS3L2 Kim et al., 2010). The gene discussed is IGF2BP2; the disease is obesity due to melanocortin 4 receptor deficiency.