PBRM1 and obesity due to melanocortin 4 receptor deficiency: The obesity SNP rs2710323, together with two diabetes SNPs, rs2590838 (r2, 0.78) and rs1108842 (r2, 0.8), are located in loci that regulate genes (TMEM110, MUSTN1, ITIH4, NEK4, GNL3, PBRM1, and NT5DC2) within a 300 kb genomic region on chromosome 3 (Supplementary Figure 3).