GPT and type 1 diabetes mellitus: Type I diabetes was induced by STZ and hyperglycemia was confirmed as shown in Figure 1A. Indeed, compared with CON groups, mice in the STZ groups developed significantly more severe liver IR injury at 6 h post-reperfusion, as demonstrated by higher levels of serum ALT (Figure 1B), severely damaged liver architecture (Figure 1C) with higher Suzuki scores (Figure 1D), and extensive hepatocellular apoptosis (Figures 1E,F).