These results are consistent with the reported inhibitory effect of RUS on p-JNK expression in a rat model of cyclosporine-induced nephropathy (Nam et al., 2013) and the ability of CoQ10 to attenuate angiotensin II-induced upregulation of p-JNK in human umbilical vein endothelial cells (Tsuneki et al., 2013). This evidence concerns the gene MAPK8 and Nephropathy.