The blockade of SKCa channels by acacetin likely also contributes to the anti-AF effect observed in canine models in addition to blocking IKur/Kv1.5, Ito/Kv4.3, and IK.ACh (Li et al., 2008; Wu et al., 2011, 2013a). This evidence concerns the gene KCNA5 and atrial fibrillation.