INS and type 1 diabetes mellitus: Neuroactive ligand-receptor interaction (p-value 3.66E-04), Type I diabetes mellitus (4.85E-04), Synaptic vesicle cycle (4.85E-04), GABAergic synapse (7.02E-04) and Insulin secretion (0.001) pathways were among those identified as significantly altered in day 34 A-T cerebellar neuronal cultures, relative to controls (Figures 5A,B).