PTGS2 and Familial adenomatous polyposis: Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is theonly FDA (Food and Drug Administration) approved drug forthe treatment of FAP (Familial adenomatous polyposis) patientsthat is known to induce apoptosis and suppressed the survivinexpression in HCT-116 cells [17].