BIRC5 and cancer: In one of the mechanism, Cdc2 gets phosphorylated, which inturn phosphorylates survivin allowing it to form complex withCdk1, thus arresting the cell cycle in G2M phase causinguncontrolled mitosis.Survivin plays a central role in inducing celldivision viaextrinsic and intrinsic apoptotic pathways.Suppression of Caspase activity via survivin inhibition bestowsresistance to apoptosis in cancer cells.