Exposure to high-fat diet (HFD) can improve survival in SOD1 mice [90] and exposure of TDP-43 mice to HFD significantly delayed AMPK phosphorylation and extended survival, thus supporting the notion that providing high-energy diet can help to rebalance bioenergetic stress in ALS pathophysiology [91]. Here, SOD1 is linked to amyotrophic lateral sclerosis.