TBK1 and amyotrophic lateral sclerosis: Given the implication that TBK1 plays a key role in ALS and the observation that some autophagy inducers, such as rapamycin, have been already shown to be promising ALS drug candidates, it seems worthwhile to explore TBK1 as a more defined target as well as envisage the use of its pharmacological activators for developing novel and targeted therapeutics for patients.