Additionally, the association of cotinine and IL-6 concentrations or the concentrations of IL-6 and ET-1 that was found in the group of smoking AP patients can indicate that oxidative stress induced by tobacco smoke amplifies the inflammatory cascade and it can be an important factor for the pathogenesis of acute pancreatitis, which in other studies were also shown [32, 34, 35]. Here, EDN1 is linked to acute pancreatitis.