To investigate further the interaction between TNFα, its receptors, and the ASK1/p38MAPK pathway in ALS, we examined the effect of selective TNFR1 or TNFR2 antagonist-neutralizing antibodies in primary astrocyte-spinal neuron cocultures expressing SOD1G93A. The gene discussed is TNFRSF1A; the disease is amyotrophic lateral sclerosis.