Inactivation of CDH1 is described to be prominently associated with tumor invasiveness, metastatic dissemination, and poor patient prognosis; the significance of CDH1 expression for metastatic potential has been shown in a variety of in vitro and in vivo models (Frixen et al., 1991; Onder et al., 2008; von Burstin et al., 2009). This evidence concerns the gene CDH1 and neoplasm.