Chronic multifocal osteomyelitis (cmo) mice carry a spontaneously acquired homozygous mutation (c.T293C, p.L98P) in Pstpip2. To date, the exact molecular contribution of Pstpip2 mutations to sterile bone inflammation remains somewhat unclear [57]. Here, PSTPIP2 is linked to chronic recurrent multifocal osteomyelitis.