EPHB1 and amyotrophic lateral sclerosis: However, at day 7 in SOD1G93A-ALS mice there was no further increase in the number of EphB1-positive motor neurons and nSTAT3-labelled astrocytes, unlike in their WT counterparts with a 1.69-fold and 1.58-fold increase of EphB1-positive motor neurons and nSTAT3 immunoreactive astrocytes post-axotomy (p = 0.011 and p = 0.010, respectively; Fig. 5f, h).