NRXN1 has been identified as a risk factor gene for diverse psychiatric disorders including schizophrenia and autism spectrum disorders.40,63,64 By analyzing the genetic interactions in fruit fly glutamatergic synapses, we have identified a novel interaction between DISC1 and a synaptic cell adhesion molecule that organizes trans-synaptic structures and functions. The gene discussed is CADM1; the disease is autism spectrum disorder.