C57BL/6 mice bearing large EG7 tumors were successfully treated with four rounds of i.t. injection of R848 (10 μg/mouse/injection), HMGN1 (10 μg/mouse/injection), and anti-PD-L1 (10 μg/mouse/injection) within two weeks, with 4 of the 5 mice becoming tumor-free (Fig. 7A & B). This evidence concerns the gene CD274 and neoplasm.