ORAI1 and tubular aggregate myopathy: On the other hand, an increase in Orai1-mediated SOCE exacerbates muscular dystrophy in mdx mice23–26 and mutations in STIM1 and Orai1 are linked to Tubular Aggregate Myopathy (TAM)27–31, an autosomal dominant muscle disease that is clinically characterized by myalgia, cramps and muscle stiffness, with or without proximal muscle weakness.