In the present study, sTg-IRBP:HELlo and sTg-IRBP:HELhi mice did not develop EAU following adoptive transfer of naïve HEL-specific CD4+ T cells (3A9 T cells) alone, but the combination of naive HEL-specific CD4+ T cells with MCMV-HEL infection 1 day post adoptive transfer resulted in intraocular inflammation. This evidence concerns the gene CD4 and infection.