Dirami et al. studied the association between the sperm-specific gene SLC26A8 (alias the testis anion transporter 1, Tat1 [MIM: 608480]) and human asthenozoospermia: in accordance with our functional results, their study revealed that although SLC26A8 and CFTR proteins interacted, the mutated forms of SLC26A8 failed to activate CFTR22. The gene discussed is CFTR; the disease is Reduced sperm motility.