Nevertheless, this study suggests that human OAT and asthenozoospermia are associated with the heterozygous mutation c.2062 G > C (p.Asp688His) in the STAS domain of  SLC26A3, and most probably, a feature that modulates the fertility in men carrying the loss-of-function allele c.949_951delGTG (p.Val318del) as reported here. The gene discussed is SLC26A3; the disease is Reduced sperm motility.