SFRP4 and Familial prostate cancer: In contrast to the study by García-Tobilla et al. 20, and in coherence with human prostate cancer tissue studies, Perry et al. 21 also detected upregulation of SFRP4 in all prostate cancer cell lines (LNCaP, PC3, DU145 and 22Rv1) compared with controls (PWR-1 and RWPE1).