SFRP4 and Familial prostate cancer: Although SFRP4 expression in prostate cancer tissue seems to deviate from this, a few prostate cell line studies have supported tumour suppressor properties of SFRP4 also in prostate cancer; Horvath et al. 13,14 showed that PC3 and LNCaP cell lines modified to overproduce SFRP4 proteins had reduced cellular proliferation compared to controls.