In contrast to these hypomethylated genes, a number of tumour suppressor genes (TSG) have been found to be hypermethylated in early HCC including HIC1, GSTP1, SOCS1, RASSF1, CDKN2A, APC, RUNX3 and PRDM2 [79], [80]. The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.