TNF and Other metabolic disease: Type 2 diabetes mellitus is a metabolic disorder that changes the anatomical and physiological integrity of the endothelium due to a permanent inflammatory condition caused by activation of T-lymphocytes, which leads to the release of pro-inflammatory cytokines such as gamma interferon (IFNγ) and tumor necrosis factor alpha (TNF-α), which increases the risk of dengue hemorrhagic fever [6].