TARDBP and amyotrophic lateral sclerosis: Analysis of the morphology of the TDP-43 inclusions in the anterior cingulate cortex from the present series demonstrated significant differences across clinicopathological groups (F(2, 52) > 4.3, p < 0.05) with more circumferential TDP-43 inclusions in FTLD-ALS cases compared to ALS and FTLD cases (posthoc p < 0.001) and significantly more rounded TDP-43 inclusions in FTLD cases compared to ALS and FTLD-ALS cases (posthoc p < 0.005) (Fig. 2).