Importantly, these circumferential TDP-43 inclusions demonstrate a striking resemblance to: 1) the TDP-43 granular neuronal cytoplasmic inclusions recently described in the frontal cortices of FTLD-TDP type B cases, all with co-existing ALS (Fig. 3e–h in [22]); 2) the TDP-43 neuronal cytoplasmic inclusions reported in the temporal cortex of ALS cases with cognitive impairment (Fig. 1 in [29]) and; 3) the granulofilamentous TDP-43 neuronal inclusions recently reported in the cortices of 7 FTLD cases [20]. The gene discussed is TARDBP; the disease is Cognitive impairment.