The present findings of significant amounts of rounded but not circumferential TDP-43 inclusions in the anterior cingulate cortex of FTLD cases, and significant amounts of circumferential but not rounded TDP-43 inclusions in the anterior cingulate cortex of FTLD-ALS cases also suggest that difficulties in reliably distinguishing between FTLD-TDP type A and B, even when attempted by experienced neuropathologists [3], may be due in part to differences in the presence of co-existing ALS in FTLD cohorts examined by different groups. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.