NLRP2 appears dysregulated in astrocytes [45, 51], and NLRP3 in microglia [34] in the context of Alzheimer’s disease as well as in other neurological diseases like Parkinson’s disease [14, 32]; additionally, NLRP2/3 are altered in pathologies that show comorbidity with AD: obesity, type-2 diabetes. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.