Securin showed an even stronger prognostic value both for all subtypes of breast carcinomas as evaluated based on the extent (p < 0.0001, HR 2.7 and CI 1.6-2.7) and the subcellular localization of immunoexpression (p = 0.003, HR 1.6, CI 1.1-2.4). The gene discussed is PTTG1; the disease is breast carcinoma.