TXNIP and type 2 diabetes mellitus: We found significantly decreased SAT TXNIP DNA methylation (p = 0.031) and in skeletal muscle increased TXNIP gene expression (p = 0.038) and borderline decreased TXNIP DNA methylation (p = 0.070) in offspring with abnormal glucose tolerance (impaired fasting glucose IFT, impaired glucose tolerance IGT, and T2DM) compared to those with normal glucose tolerance (Table 4).