This is in line with previous findings of an inverse association between blood TXNIP DNA methylation levels and fasting plasma glucose and Hba1c levels, and between blood TXNIP DNA methylation and risk of T2DM [14–16, 18, 19], as well as decreased blood TXNIP DNA methylation in subjects with T2DM compared to controls [17]. This evidence concerns the gene TXNIP and type 2 diabetes mellitus.