The increased SAT TXNIP DNA methylation in O-GDM in our cohort is furthermore in contrast to the findings of TXNIP blood and skeletal muscle hypomethylation with increasing Hba1c levels, increased risk of T2DM and overt T2DM [14–18], but the different tissues studied could explain the different results. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.