A high TXNIP DNA methylation percentage at CpG site cg19693031 in blood has consistently been associated with lower fasting blood glucose, HbA1c and/or HOMA-IR levels, as well as a lower prevalence and a decreased risk of type 2 diabetes (T2DM) in different studies [14–19]. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.