We therefore conducted a combined analysis of the two trials including the primary end-point asthma/recurrent wheeze by age 3 years as well as the secondary end-points specific IgE, total IgE, eczema and lower respiratory tract infections (LRTI) and did 25(OH)D level-based analyses to determine whether nutritional status at entry to the trials influenced the effect of vitamin D. The gene discussed is IGHE; the disease is Recurrent lower respiratory tract infections.