25 Holder Holder JL JL Jr Jr Butte Butte NF NF Zinn Zinn AR AR Profound obesity associated with a balanced translocation that disrupts the SIM 1 gene Profound obesity associated with a balanced translocation that disrupts the SIM 1 gene Hum Mol Genet Hum Mol Genet 2000 2000 9 9 101 101 108 108 10587584 10587584. Here, AR is linked to obesity due to melanocortin 4 receptor deficiency.