20 Krude Krude H H Biebermann Biebermann H H Luck Luck W W Horn Horn R R Brabant Brabant G G Grüters Grüters A A Severe early-onset obesity, adrenal insu= ciency and red hair pigmentation caused by POMC mutations in humans Severe early-onset obesity, adrenal insu= ciency and red hair pigmentation caused by POMC mutations in humans Nat Genet Nat Genet 1998 1998 19 19 155 155 157 157 9620771 9620771. Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.