17 Clément Clément K K Vaisse Vaisse C C Lahlou Lahlou N N Cabrol Cabrol S S Pelloux Pelloux V V Cassuto Cassuto D D Gourmelen Gourmelen M M Dina Dina C C Chambaz Chambaz J J Lacorte Lacorte JM JM Basdevant Basdevant A A Bougneres Bougneres P P Lebouc Lebouc Y Y Froguel Froguel P P Guy-Grand Guy-Grand B. B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction Nature Nature 1998 1998 392 392 398 398 401 401 9537324 9537324. The gene discussed is LEPR; the disease is obesity disorder.