22 Yeo Yeo GS GS Farooqi Farooqi IS IS Aminian Aminian S S Halsall Halsall DJ DJ Stanhope Stanhope RG RG O’Rahilly O’Rahilly S. S. A frameshift mutation in MC4R associated with dominantly inherited human obesity A frameshift mutation in MC4R associated with dominantly inherited human obesity Nat Genet Nat Genet 1998 1998 20 20 111 111 112 112 9771698 9771698. The gene discussed is MC4R; the disease is obesity disorder.