20 Krude Krude H H Biebermann Biebermann H H Luck Luck W W Horn Horn R R Brabant Brabant G G Grüters Grüters A A Severe early-onset obesity, adrenal insu= ciency and red hair pigmentation caused by POMC mutations in humans Severe early-onset obesity, adrenal insu= ciency and red hair pigmentation caused by POMC mutations in humans Nat Genet Nat Genet 1998 1998 19 19 155 155 157 157 9620771 9620771. The gene discussed is POMC; the disease is Obesity.