CF develops at a young age and is associated with genetic mutation in the CF transmembrane conductance regulator gene, whereas the etiology in patients with NCFBE is heterogeneous and the cause cannot be established in many patients (idiopathic bronchiectasis).(19) NCFBE is more prevalent than CF, its prevalence increases with advanced age, it is more frequent in women and the Asian population, and in contrast to CF occurs commonly in the lower lobe of the lungs, which makes the mucociliary clearance more difficult.(20). The gene discussed is CFTR; the disease is cystic fibrosis.